Digit-Threatening Severe Tophaceous Gout

نویسندگان
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Ulcerated tophaceous gout.

Gout is often considered a disease of an excessive lifestyle, a 'malady of kings'. Today, more than 1% of the European and US populations are afflicted with gout, although ulceration over gout tophi remains uncommon. We describe four cases of ulceration associated with gout tophi to highlight the clinical presentation, complications and a management strategy.

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Urate oxidase (rasburicase) for treatment of severe tophaceous gout.

Gout is a clinical disorder caused by deposition of urate crystals in a joint leading to acute inflammatory response with acute pain. In severe and longstanding gout, the crystals accumulate in soft tissues such as cartilage, subcutaneous tissue or even veins leading to the development of tophi responsible for very large deposit formations and disability. Most cases of gout present with the sud...

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Chronic tophaceous gout.

A 44 year old man presented with a 15-day history of painful swelling of right middle finger, which was also red, warm, and tender. A tooth paste like, chalky substance was expressible on pressure from the swelling. The patient reported that he had occasional episodes of joint pains involving both small and large joints of the extremities. He denied a history of medication intake and past histo...

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[Chronic tophaceous gout].

A 51-year-old immigrant from the Caucasus had had chronic tophaceous gout for over 20 years, but had never been treated with anti-hyperuricemic drugs. He had developed large, multiple tophi in many locations, including both ankles and feet. The enormous size and unique location of the tophi caused considerable pain, and difficulty in standing and on walking. Since surgical removal of the tophi ...

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ژورنال

عنوان ژورنال: Journal of General Internal Medicine

سال: 2015

ISSN: 0884-8734,1525-1497

DOI: 10.1007/s11606-015-3548-3